Diagnostic Histopathology
Volume 14, Issue 4 , Pages 164-174 , April 2008

Renal epithelial and stromal tumor: a new term to encompass the spectrum of cystic nephroma and mixed epithelial and stromal tumor of the kidney

References 

  1. Hartman DS, Davis CJ, Johns T, Goldman SM. Cystic renal cell carcinoma. Urology. 1986;28:145–153
  2. Murad T, Komaiko W, Oyasu K, Bauer R. Multilocular cystic renal cell carcinoma. Am J Clin Pathol. 1991;95:633–637
  3. Eble JN, Bonsib SM. Extensively cystic renal neoplasms: cystic nephroma, cystic partially differentiated nephroblastoma, multilocular cystic renal cell carcinoma, and cystic hamartoma of renal pelvis. Semin Diagn Pathol. 1998;15:2–20
  4. Truong LD, Choi YJ, Shen SS, Ayala G, Amato R, Krishnan B. Renal cystic neoplasms and renal neoplasms associated with cystic renal diseases: pathogenetic and molecular links. Adv Anat Pathol. 2003;10:135–159
  5. Eble JN, Sauter G, Epstein JI. World Health Organization classification of tumours. Pathology and genetics of tumours of the urinary system and male genital organs. Lyon: IARC Press; 2004;76–78
  6. Edmunds W. Cystic adenoma of the kidney. Trans Pathol Soc (Lond). 1892;43
  7. Osathanondh V, Potter EL. Pathogenesis of polycystic kidneys. Historical survey. Arch Pathol. 1964;77:459–465
  8. Tang TT, Harb JM, Oechler HW, et al. Multilocular renal cyst: electron microscopic evidence of pathogenesis. Am J Pediatr Hematol Oncol. 1984;6:27–32
  9. Joshi VV, Beckwith JB. Multilocular cyst of the kidney (cystic nephroma) and cystic, partially differentiated nephroblastoma. Terminology and criteria for diagnosis. Cancer. 1989;64:466–479
  10. Kajani N, Rosenberg BF, Bernstein J. Multilocular cystic nephroma. J Urol Pathol. 1993;1:33–42
  11. Madewell JE, Goldman SM, Davis CJ, et al. Multilocular cystic nephroma: a radiographic-pathologic correlation of 58 patients. Radiology. 1983;146:309–321
  12. Turbiner J, Amin MB, Humphrey PA, et al. Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. Am J Surg Pathol. 2007;31:489–500
  13. Jevremovic D, Lager DJ, Lewin M. Cystic nephroma (multilocular cyst) and mixed epithelial and stromal tumor of the kidney: a spectrum of the same entity?. Ann Diagn Pathol. 2006;10:77–82
  14. Antic T, Perry KT, Harrison K, et al. Mixed epithelial and stromal tumor of the kidney and cystic nephroma share overlapping features: reappraisal of 15 lesions. Arch Pathol Lab Med. 2006;130:80–85
  15. Mukhopadhyay S, Valente AL, de la Roza G. Cystic nephroma: a histologic and immunohistochemical study of 10 cases. Arch Pathol Lab Med. 2004;128:1404–1411
  16. Block NL, Grabstald HG, Melamed MR. Congenital mesoblastic nephroma (leiomyomatous hamartoma): first adult case. J Urol. 1973;110:380–383
  17. Durham JR, Bostwick DG, Farrow GM, et al. Mesoblastic nephroma of adulthood. Report of three cases. Am J Surg Pathol. 1993;17:1029–1038
  18. Mensch LS, Trainer TD, Plante MK. Cystic hamartoma of the renal pelvis: a rare pathologic entity. Mod Pathol. 1999;12:417–421
  19. Pawade J, Soosay GN, Delprado W, Parkinson MC, Rode J. Cystic hamartoma of the renal pelvis. Am J Surg Pathol. 1993;17:1169–1175
  20. Trillo AA. Adult variant of congenital mesoblastic nephroma. Arch Pathol Lab Med. 1990;114:533–535
  21. Truong LD, Williams R, Ngo T, et al. Adult mesoblastic nephroma: expansion of the morphologic spectrum and review of literature. Am J Surg Pathol. 1998;22:827–839
  22. Tulbah A, Kardar AH, Akhtar M. Mesoblastic nephroma in an adult. J Urol Pathol. 1997;6:67–73
  23. Michal M, Syrucek M. Benign mixed epithelial and stromal tumor of the kidney. Pathol Res Pract. 1998;194:445–448
  24. Adsay NV, Eble JN, Srigley JR, Jones EC, Grignon DJ. Mixed epithelial and stromal tumor of the kidney. Am J Surg Pathol. 2000;24:958–970
  25. Michal M, Hes O, Bisceglia M, et al. Mixed epithelial and stromal tumors of the kidney. A report of 22 cases. Virchows Arch. 2004;445:359–367
  26. Michal M. Benign mixed epithelial and stromal tumor of the kidney. Pathol Res Pract. 2000;196:275–276
  27. Svec A, Hes O, Michal M, Zachoval R. Malignant mixed epithelial and stromal tumor of the kidney. Virchows Arch. 2001;439:700–702
  28. Sukow WR, Cheville JC, Lager DJ, Lewin JR, Sebo TJ, Lewin M. Malignant mixed epithelial and stromal tumor of the kidney with rhabdoid features: report of a case including immunohistochemical, molecular genetic studies and comparison to morphologically similar renal tumors. Hum Pathol. 2007;38:1432–1437
  29. Sharma JB, Aruna J, Mittal S, Sharma MC. Mixed epithelial and stromal tumor of the kidney in a puerperal woman. J Obstet Gynaecol Res. 2007;33:574–577
  30. da Silva CS, Adad SJ, Saldanha JC, Cancado CG, Bachi C, Murta EF. Synchronous Sertoli cell and serous cystadenoma tumors of the ovaries with mixed epithelial and stromal tumor of the kidney: a case report. Clin Genitourin Cancer. 2007;5:338–340
  31. Mai KT, Elkeilani A, Veinot JP. Mixed epithelial and stromal tumor (MEST) of the kidney: report of 14 cases with male and PEComatous variants and proposed histopathogenesis. Pathology. 2007;39:235–240
  32. Kwon JE, Kang JH, Kwon GY. Mixed epithelial and stromal tumor of the kidney: a case report. J Korean Med Sci. 2007;22:159–162
  33. Rauf F, Yaqoob N, Husain A. Mixed epithelial and stromal tumor of the kidney. J Pak Med Assoc. 2006;56:340–341
  34. Ekici AI, Ekici S, Gurel B, Altinok G, Erkan I, Gungen Y. Benign mixed epithelial and stromal tumor of the kidney. Scientific World Journal. 2006;1:615–618
  35. Chou HP, Ou YC, Cheng CL, Yang CR. Mixed epithelial and stromal tumor of the kidney. J Chin Med Assoc. 2006;69:140–142
  36. Parikh P, Chan TY, Epstein JI, Argani P. Incidental stromal-predominant mixed epithelial and stromal tumors of the kidney. Arch Pathol Lab Med. 2005;129:910–914
  37. Beiko DT, Nickel JC, Boag AH, Srigley JR. Benign mixed epithelial and stromal tumor of the kidney of possible müllerian origin. J Urol. 2001;166:1381–1382
  38. Clement PB. Histology of the ovary. In:  Sternberg SS editors. Histology for pathologists. London: Lippincott Williams & Wilkins; 1997;p. 934–937
  39. Steele R, Daroca PJ, Hill S, Reed RJ, Thomas R. Multilocular renal cyst (cystic nephroma) with mullerian-like stroma. Urology. 1994;43:549–553
  40. Buritica C, Serrano M, Zuluaga A, Arrabal M, Regauer S, Nogales FF. Mixed epithelial and stromal tumor of the kidney with luteinized ovarian stroma. J Clin Pathol. 2007;60:98–100
  41. Shimokama T, Watanabe T. Multilocular renal cyst. Scanning and transmission electron microscopic observations. Pathol Res Pract. 1989;184:255–259
  42. Coleman M. Multilocular renal cyst, case report, ultrastructure and review of the literature. Virchow Arch. 1980;387:207–219
  43. Pierson CR, Schober MS, Wallis T, et al. Mixed epithelial and stromal tumor of the kidney lacks the genetic alterations of cellular congenital mesoblastic nephroma. Hum Pathol. 2001;32:513–520
  44. Comperat E, Couturier J, Peyromaure M, Cornud F, Vieillefond A. Benign mixed epithelial and stromal tumor of the kidney (MEST) with cytogenetic alteration. Pathol Res Pract. 2005;200:865–867
  45. Azoulay S, Vieillefond A, Paraf F, et al. Tubulocystic carcinoma of the kidney: a new entity among renal tumors. Virchows Arch. 2007;451:905–909
  46. Amin MB, MacLennan GT, Paraf F, et al. Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 29 cases of a distinctive rare subtype of renal cell carcinoma. Mod Pathol. 2004;17:137A
  47. Fine SW, Reuter VE, Epstein JI, Argani P. Angiomyolipoma with epithelial cysts (AMLEC): a distinct cystic variant of angiomyolipoma. Am J Surg Pathol. 2006;30:593–599
  48. Davies CJ, Barton JH, Sesterhenn IA. Cystic angiomyolipoma of the kidney: a clinicopathologic description of 11 cases. Mod Pathol. 2006;19:669–674
  49. Armah HB, Yin M, Rao UN, Parwani AV. Angiomyolipoma with epithelial cysts (AMLEC): a rare but distinct variant of angiomyolipoma. Diagn Pathol. 2007;21:11
  50. Hamilton SR, Aaltonen LA. World Health Organization classification of tumours. Pathology and genetics of tumours of the digestive system. Lyon: IARC Press; 2000;p. 182–3; p. 234–6
  51. Thompson LD, Becker RC, Przygodzki RM, Adair CF, Heffess CS. Mucinous cystic neoplasm (mucinous cystadenocarcinoma of low-grade malignant potential) of the pancreas: a clinicopathologic study of 130 cases. Am J Surg Pathol. 1999;23:1–16
  52. Zamboni G, Scarpa A, Bogina G, et al. Mucinous cystic tumors of the pancreas: clinicopathological features, prognosis, and relationship to other mucinous cystic tumors. Am J Surg Pathol. 1999;23:410–422
  53. Akwari OE, Tucker A, Seigler HF, et al. Hepatobiliary cystadenoma with mesenchymal stroma. Ann Surg. 1990;211:18–27
  54. Devaney K, Goodman ZD, Ishak KG. Hepatobiliary cystadenoma and cystadenocarcinoma: a light microscopic and immunohistochemical study of 70 patients. Am J Surg Pathol. 1994;18:1078–1091
  55. Carabias E, Garcia Munoz H, Dihmes FP, et al. Primary mucinous cystadenocarcinoma of the retroperitoneum. Report of a case and literature review. Virchows Arch. 1995;426:641–645
  56. Mourra N, Balladur P, Parc R, Flejou J-F. Intrasplenic mucinous cystadenoma with mesenchymal stroma arising in pancreatic heterotopias. Histopathology. 2003;42:616–617
  57. Izumo A, Yamaguchi K, Eguchi T, et al. Mucinous cystic tumor of the pancreas: immunohistochemical assessment of “ovarian-type stroma”. Oncol Rep. 2003;10:515–525
  58. Ridder GJ, Maschek H, Flemming P, Nashan B, Klempnauer J. Ovarian-like stroma in an invasive mucinous cystadenocarcinoma of the pancreas positive for inhibin. A hint concerning its possible histogenesis. Virchows Arch. 1998;432:451–454
  59. Yeh MM, Tang LH, Wang S, Robert ME, Zheng W, Jain D. Inhibin expression in ovarian-type stroma in mucinous cystic neoplasms of the pancreas. Appl Immunohistochem Mol Morphol. 2004;12:148–152
  60. Tickoo SK, Gopalan A, Tu JJ, et al. Estrogen and progesterone-receptor-positive stroma as a non-tumorous proliferation in kidneys: a possible metaplastic response to obstruction. Mod Pathol. 2008;21:60–65
  61. Bastian PJ, Kuhlmann R, Vogel J, et al. Local recurrence of a unilateral cystic nephroma. Int J Urol. 2004;11:329–331
  62. Luithle T, Furtwangler R, Graf N, Fuchs J, SIOP/GPOH Study Group . Treatment of cystic nephroma and cystic partially differentiated nephroblastoma—a report from the SIOP/GPOH study group. J Urol. 2007;177:294–296
  63. Omar AM, Khattak AQ, Lee AJ. Cystic renal cell carcinoma arising from multilocular cystic nephroma of the same kidney. Int Braz J Urol. 2006;32:187–189
  64. Nakagawa T, Kanai Y, Fujimoto H, et al. Malignant mixed epithelial and stromal tumours of the kidney: a report of the first two cases with a fatal clinical outcome. Histopathology. 2004;44:302–304
  65. Yap YS, Coleman M, Olver I. Aggressive mixed epithelial-stromal tumour of the kidney treated with chemotherapy and radiotherapy. Lancet Oncol. 2004;5:747–749
  66. Davies CJ, Sesterhenn IA. Pathology of 68 renal epithelial-stromal tumors. Mod Pathol. 2006;19:134A

PII: S1756-2317(08)00032-7

doi: 10.1016/j.mpdhp.2008.02.008

Diagnostic Histopathology
Volume 14, Issue 4 , Pages 164-174 , April 2008