Diagnostic Histopathology
Volume 14, Issue 8 , Pages 388-400 , August 2008

Sex cord-stromal tumours of the ovary: a review highlighting recent advances

References 

  1. Scully RE, Young RH, Clement PB. Sex cord-stromal tumors. In: Tumors of the Ovary and Maldeveveloped Gonads, Atlas of Tumour Pathology, third series, fascicle 23. Washington DC: Armed Force Institute of Pathology; 1998;p. 169–238
  2. Young RH, Scully RE. Differential diagnosis of ovarian tumours based primarily on their patterns and cell types. Semin Diagn Pathol. 2001;18:161–235
  3. McCluggage WG, Young RH. Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumours. Semin Diagn Pathol. 2005;22:3–32
  4. Baker PM, Oliva E. Immunohistochemistry as a tool in the differential diagnosis of ovarian tumours: an update. Int J Gynecol Pathol. 2004;74:39–55
  5. Young RH, Scully RE. Ovarian sex cord stromal tumors: recent advances and current status. Clin Obstet Gynaecol. 1984;11:93–134
  6. Aguirre P, Thor AD, Scully RE. Ovarian endometrioid carcinomas resembling sex cord-stromal tumors. An immunohistochemical study. Int J Gynecol Pathol. 1989;8:364–373
  7. Young RH. A brief history of the pathology of the gonads. Mod Pathol. 2005;18:S3–S17
  8. Clement PB, Young RH. Atlas of gynecological surgical pathology. 2nd edn.. Philadelphia: WB Saunders; 2008;
  9. Zaloudek C, Norris HJ. Granulosa tumors of the ovary in children. A clinical and pathological study of 32 cases. Am J Surg Pathol. 1982;6:503–512
  10. Young RH, Dickersin GR, Scully RE. Juvenile granulosa cell tumor of the ovary. A clinicopathological analysis of 125 cases. Am J Surg Pathol. 1984;8:575–596
  11. Schumer ST, Cannistra SA. Granulosa cell tumour of the ovary. J Clin Oncol. 2003;21:1180–1189
  12. Stenwig JT, Hazekamp JT, Beecham JH. Granulosa cell tumors of the ovary. A clinicopathological study of 118 cases with long term follow-up. Gynecol Oncol. 1979;7:136–152
  13. Villella J, Herrmann FR, Kaul S, et al. Clinical and pathological predictive factors in women with adult-type granulosa cell tumor of the ovary. Int J Gynecol Pathol. 2007;26:154–159
  14. Zanagnolo V, Pasinetti B, Sartori E. Clinical review of 63 cases of sex cord stromal tumors. Eur J Gynaecol Oncol. 2004;XXV:431–437
  15. Young RH. Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. Mod Pathol. 2005;18:S81–S98
  16. Dougal D. A granulosa cell tumour of tubular or adenomatous type. J Obstet Gynaecol. 1945;52:370–371
  17. Irving J, Young RH. Granulosa cell tumors of the ovary with a pseudopapillary pattern: a study of 14 cases of an unusual morphologic variant emphasizing their distinction from transitional cell neoplasms and other papillary ovarian tumors. Am J Surg Pathol. 2008;32:581–586
  18. Young RH, Scully RE. Ovarian sex cord-stromal tumours with bizarre nuclei: a clinicopathologic analysis of 17 cases. Int J Gynecol Pathol. 1983;1:325–335
  19. Young RH, Oliva E, Scully RE. Luteinized adult granulosa cell tumours of the ovary: a report of four cases. Int J Gynecol Pathol. 1994;13:302–310
  20. Ahmed E, Young RH, Scully RE. Adult granulosa cell tumor of the ovary with foci of hepatic cell differentiation: a report of four cases and comparison with two cases of granulosa cell tumor with Leydig cells. Am J Surg Pathol. 1999;9:1089–1093
  21. Price A, Russell P, Elliott P, Bannatyne P. Composite mucinous and granulosa-cell tumor of ovary: case report of a unique neoplasm. Int J Gynecol Pathol. 1990;9:372–378
  22. Chandran R, Rahman H, Gebbie D. Composite mucinous and granulosa-theca-cell tumour of the ovary: an unusual neoplasm. Aust N Z J Obstet Gynaecol. 1993;33:437–439
  23. Kushida Y, Haba R, Kadota K, et al. Composite mucinous and granulosa cell tumor of the ovary. Pathol Int. 2005;55:797–801
  24. Irving JA, Abdulmohsen A, Young RH, Clement PB. Cellular fibromas of the ovary: A study of 75 cases including 40 mitotically active tumors emphasizing their distinction from fibrosarcoma. Am J Surg Pathol. 2006;30:929–938
  25. Prat J, Scully RE. Cellular fibromas and fibrosarcomas of the ovary: a comparative clinicopathologic analysis of seventeen cases. Cancer. 1981;47:2663–2670
  26. Young RH, Scully RE. Ovarian stromal tumors with minor sex cord elements; a report of seven cases. Int J Gynecol Pathol. 1983;2:227–234
  27. Zhang J, Young RH, Arseneau I, et al. Ovarian stromal tumors containing lutein or Leydig cells (luteinized thecomas and stromal Leydig cells) - a clinicopathological analysis of fifty cases. Int J Gynecol Pathol. 1982;1:270–285
  28. Clement PB, Young RH, Hanna W, Scully RE. Sclerosing peritonitis associated with luteinized thecomas of the ovary. A clinicopathological analysis of six cases. Am J Surg Pathol. 1994;18:1–13
  29. Staats PN, McCluggage WG, Clement PB, Young RH. Luteinized thecomas (thecomatosis) of the type typically associated with sclerosing peritonitis: a clinical, histopathological and immunohistochemical analysis of 27 cases. Am J Surg Pathol, in press.
  30. Chalvardijian A, Scully RE. Sclerosing stromal tumors of the ovary. Cancer. 1973;31:664–670
  31. Ramzy I. Signet ring stromal tumour of the ovary. Histochemical, light and electron microscopic study. Cancer. 1976;38:166–172
  32. Vang R, Bague S, Tavassoli F, Prat J. Signet-ring stromal tumor of the ovary: clinicopathologic analysis and comparison with Krukenberg tumor. Int J Gynecol Pathol. 2003;23:45–51
  33. Irving JA, Young RH. Microcystic stromal tumor of the ovary; report of 12 cases of a hitherto uncharacterized distinctive ovarian neoplasm. Mod Pathol. 2008;21(Suppl):207a
  34. Henley JD, Young RH, Ulbright TM. Malignant Sertoli cell tumors of the testis: a study of 13 examples of a neoplasm frequently misinterpreted as seminoma. Am J Surg Pathol. 2002;26:541–550
  35. Oliva E, Alvarez T, Young RH. Sertoli cell tumours of the ovary, a clinicopathological and immunohistochemical study of 54 cases. Am J Surg Pathol. 2005;29:143–156
  36. Young RH, Scully RE. Ovarian Sertoli-Leydig cell tumors: a clinicopathological analysis of 207 cases. Am J Surg Pathol. 1985;9:543–569
  37. Gagnon S, Tetu B, Silva EG, McCaughey WTE. Frequency of alpha fetoprotein production by Sertoli-Leydig cell tumors of the ovary: an immunohistochemical study of eight cases. Mod Pathol. 1989;2:63–67
  38. Zaloudek C, Norris HJ. Sertoli-Leydig tumors of the ovary. A clinicopathologic study of 64 intermediate and poorly differentiated neoplasms. Am J Surg Pathol. 1984;8:405–418
  39. Young RH, Scully RE. Ovarian Sertoli-Leydig cell tumors with a retiform pattern: a problem in histopathologic diagnosis. A report of 25 cases. Am J Surg Pathol. 1983;7:755–771
  40. Young RH, Scully RE. Well-differentiated ovarian Sertoli-Leydig cell tumors: a clinicopathological analysis of 23 cases. Int J Gynecol Pathol. 1984;3:277–290
  41. Young RH, Prat J, Scully RE. Ovarian Sertoli-Leydig cell tumors with heterologous elements. (i). Gastrointestinal epithelium and carcinoid: a clinicopathologic analysis of thirty-six cases. Cancer. 1982;50:2448–2456
  42. Prat J, Young RH, Scully RE. Ovarian Sertoli-Leydig cell tumors with heterologous elements. (ii). Cartilage and skeletal muscle. A clinicopathologic analysis of twelve cases. Cancer. 1982;50:2465–2475
  43. McCluggage WG, Young RH. Ovarian Sertoli-Leydig cell tumors with pseudoendometrioid tubules (pseudoendometrioid Sertoli-Leydig cell tumors). Am J Surg Pathol. 2007;31:592–596
  44. Roth LM, Slayton RE, Brady LW, Blessing JA, Johnson G. Retiform differentiation in ovarian Sertoli-Leydig cell tumors. A clinicopathologic study of six cases from a gynaecologic oncology study group. Cancer. 1985;55:1093–1098
  45. Talerman A. Ovarian Sertoli-Leydig cell tumor (androblastoma) with retiform pattern: a clinicopathologic study. Cancer. 1987;60:3056–3064
  46. Young RH. From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part I. Adv Anat Pathol. 2006;13:205–227

PII: S1756-2317(08)00096-0

doi: 10.1016/j.mpdhp.2008.06.011

Diagnostic Histopathology
Volume 14, Issue 8 , Pages 388-400 , August 2008

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