Diagnostic Histopathology
Volume 15, Issue 12 , Pages 554-563, December 2009

Molecular genetics of endometrial carcinoma

Lluis Catasus PhD is from the Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain

Alberto Gallardo MD is from the Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain

Jaime Prat MD FRCPath is from the Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Avda. Sant Antoni Ma Claret 167, 08025 Barcelona, Spain

published online 09 October 2009.

Abstract 

Two different clinicopathologic subtypes of endometrial carcinoma are recognized: the estrogen-related (type I, endometrioid) and the non-estrogen related (type II, non-endometrioid). The clinicopathological differences are paralleled by specific genetic alterations with type I showing microsatellite instability and mutations in PTEN, PIK3CA, K-RAS, and CTNNB1 (beta-catenin), and type II exhibiting p53 mutations and chromosomal instability. This article reviews the genetic changes of endometrial carcinogenesis in the light of morphologic features of the tumors and their precursors.

Keywords: beta-catenin, chromosomal instability, EEC, endometrial carcinoma, K-RAS, MI, NEEC, PIK3CA, PTEN, P53

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PII: S1756-2317(09)00174-1

doi:10.1016/j.mpdhp.2009.09.002

Diagnostic Histopathology
Volume 15, Issue 12 , Pages 554-563, December 2009

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