Diagnostic Histopathology RSS feed: Current Issue. This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section. Both the contributors and readership are seen as being International. The trend toward continuing education/accreditation has a strong influence in the shaping of the journal's content and is reflected in the inclusion of a self-assessment section. http://www.diagnostichistopathology.co.uk/?rss=yesElsevier Inc.en © 2009 Published by Elsevier Inc. All rights reserved. Diagnostic Histopathology1756-2317163March 2010 © 2009 Published by Elsevier Inc. All rights reserved. healthpermissions@elsevier.comhttp://www.diagnostichistopathology.co.uk/article/PIIS1756231710000228/abstract?rss=yesEditorial board10.1016/S1756-2317(10)00022-8Diagnostic Histopathology 16, 3 (2010)2010-03-01Diagnostic Histopathology2010-03-01163S1756-2317(10)X0003-2iihttp://www.diagnostichistopathology.co.uk/article/PIIS1756231709002321/abstract?rss=yesIn the February 2010 issue of Diagnostic Histopathology we concentrated on lymphomas in nodal and extranodal sites. While the 2008 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues includes descriptions of manifestations of these neoplasms in the blood and bone marrow, the bone marrow biopsy (BMB) receives less emphasis, particularly in lymphoid lesions. Routine trephine biopsy of the bone marrow as a diagnostic tool is relatively recent, dating from 1958. The BMB requires decalcification prior to conventional processing and the optimum method to obtain the best compromise between speed of processing and morphology and, more recently, suitability for molecular diagnostic techniques, has not yet been resolved. Both resin embedding and paraffin embedding have had their advocates and while excellent results are obtainable by modern resin embedding that allows a combination of rapid processing, excellent morphology, immunocytochemistry and DNA analysis, paraffin embedding has become the standard method. Ultrasonic decalcification and other refinements in decalcification and processing may potentially further reduce the delay and artefacts associated with traditional methods.EditorialElizabeth J. Soilleux, Jon van der Walt10.1016/j.mpdhp.2009.12.011Diagnostic Histopathology 16, 3 (2010)2010-02-01Diagnostic Histopathology2010-02-01163S1756-2317(10)X0003-2Mini-Symposium: Haematopathology Update II115115http://www.diagnostichistopathology.co.uk/article/PIIS175623170900228X/abstract?rss=yesAbstract: Splenectomy is undertaken for diagnosis, and in later stages of management, of patients with a diverse range of lymphomas. High quality histological sections, requiring careful attention to tissue fixation, are needed to assess these lesions adequately. Increasing use of fine-needle aspiration, needle core biopsy and laparoscopic surgery add further diagnostic challenges. In addition to involvement by dissemination of lymphomas based primarily in lymph nodes, bone marrow or other tissues, spleen is the predominant site of disease in several distinctive types of lymphoma. In particular, splenic marginal zone B-cell lymphoma, hairy cell leukaemia and T-cell and macrophage-rich large B-cell lymphoma are recognized as clinicopathologically distinct entities. Research into the cellular and molecular origins of these lymphomas is ongoing; variants and new entities are becoming evident. Histological and immunohistochemical features of the spleen following treatment for lymphoma are complex and may cause diagnostic confusion. Inflammatory and reactive processes in the spleen can also provide clinical, radiological or pathological mimicry of lymphomatous involvement.Lymphomas involving the spleenBridget S. Wilkins10.1016/j.mpdhp.2009.12.007Diagnostic Histopathology 16, 3 (2010)2010-03-01Diagnostic Histopathology2010-03-01163S1756-2317(10)X0003-2116124http://www.diagnostichistopathology.co.uk/article/PIIS1756231709002291/abstract?rss=yesAbstract: Lymphomatous infiltrates are most commonly encountered in a bone marrow biopsy (BMB) taken for lymphoma staging or for diagnosis of a suspected haematological abnormality. Crucial for staging, the BMB may show classic and variant patterns of lymphomatous infiltration and immunoprofile. Exceptions to the common profiles may be associated with variant cytogenetics and have prognostic implications. Diagnosis should be multifaceted and flow cytometry and molecular studies may be required to arrive at a final diagnosis. Assessment of haematopoiesis should be included in all reports.In follow-up biopsies, disease bulk may be markedly reduced and reactive lymphoid proliferation may complicate the morphological assessment. Transformation of the original lymphoma to a higher grade or the development of a new type of lymphoma may occur or the BMB may be discordant with the lymph node diagnosis. Plasma cell myeloma and related disorders must be considered in the differential diagnosis of lymphoid proliferations with plasmacytic and plasmablastic differentiation. Diffuse interstitial lymphocytosis, lymphoid aggregates, lymphoid follicles with germinal centres and reactive lymphohistiocytic infiltrates may mimic lymphomas.Lymphomas in the bone marrowJon D. van der Walt10.1016/j.mpdhp.2009.12.008Diagnostic Histopathology 16, 3 (2010)2010-02-15Diagnostic Histopathology2010-02-15163S1756-2317(10)X0003-2125142http://www.diagnostichistopathology.co.uk/article/PIIS1756231709002308/abstract?rss=yesAbstract: The thymus is an anterior mediastinal lymphoid organ important for immunological self-tolerance that comprises epithelial, lymphocytic, histiocytic and stromal elements with characteristic histological arrangements. Its complex embryological development means that dysgenesis and embryological remnants may be seen and rarely lead to sequelae such as tumours. Thymic biopsy or thymectomy may be performed for diagnostic reasons, although thymectomy is more commonly performed as a treatment, usually for myaesthenia gravis or tumours. The major categories of thymic pathology include cysts, hyperplasia, thymomas, haematopoietic neoplasms, primary and secondary carcinomas, neuroendocrine tumours, germ cell tumours and soft tissue tumours.Surgical pathology of the thymus and mediastinumElizabeth J. Soilleux10.1016/j.mpdhp.2009.12.009Diagnostic Histopathology 16, 3 (2010)2010-01-20Diagnostic Histopathology2010-01-20163S1756-2317(10)X0003-2143160http://www.diagnostichistopathology.co.uk/article/PIIS175623170900231X/abstract?rss=yesMelanocytic lesionsColin Moyes, Karen Blessing10.1016/j.mpdhp.2009.12.010Diagnostic Histopathology 16, 3 (2010)2010-01-25Diagnostic Histopathology2010-01-25163S1756-2317(10)X0003-2Self-assessment161165