Diagnostic Histopathology RSS feed: Current Issue. This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and illustrated case reports. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. The journal aims to cover the main breadth of hsitopathology in a three yearly cycle. Both the contributors and readership are seen as being International. The trend toward continuing education/accreditation has a strong influence in the shaping of the journal's content and is reflected in the inclusion of a self-assessment section. http://www.diagnostichistopathology.co.uk/?rss=yesElsevier Inc.en © 2012 Published by Elsevier Inc. All rights reserved. Diagnostic Histopathology1756-2317185May 2012 © 2012 Published by Elsevier Inc. All rights reserved. healthpermissions@elsevier.comhttp://www.diagnostichistopathology.co.uk/article/PIIS1756231712000643/abstract?rss=yesEditorial board10.1016/S1756-2317(12)00064-3Diagnostic Histopathology 18, 5 (2012)2012-05-01Diagnostic Histopathology2012-05-01185S1756-2317(12)X0005-7iihttp://www.diagnostichistopathology.co.uk/article/PIIS1756231712000369/abstract?rss=yesAbstract: Distal villous immaturity (DVI) is a placental phenotype characterized by enlarged distal villi with excessive stroma, hypercellular villous trophoblast, paucity of vasculosyncytial membranes, and a decreased fetoplacental weight ratio. It is predominantly observed in term or near-term placentas and is associated with specific maternal conditions including impaired glucose tolerance, obesity, and excessive pregnancy weight gain. A similar phenotype is observed in placentas with hypercoiling of the umbilical cord. DVI is also occasionally seen in the placentas of preterm infants with idiopathic fetal growth restriction, congenital malformations, and genetic or chromosomal abnormalities. In infants of diabetic mothers, DVI may in part be a consequence of excessive maternal glucose leading to release of fetal insulin and other growth factors that promote excessive placental growth at the expense of villous maturation. Adverse outcomes associated with DVI include intrauterine fetal death (IUFD), fetal growth restriction (FGR), and, more speculatively, late gestational hypoxia and chronic diseases of childhood and later adult life.Distal villous immaturityRaymond W. Redline10.1016/j.mpdhp.2012.02.002Diagnostic Histopathology 18, 5 (2012)2012-03-19Diagnostic Histopathology2012-03-19185S1756-2317(12)X0005-7Mini-Symposium: Placental and Trophoblastic Pathology189194http://www.diagnostichistopathology.co.uk/article/PIIS1756231712000394/abstract?rss=yesAbstract: Distal villous hypoplasia is a form of placental villous maldevelopment that has the potential to cause significant intrauterine growth restriction with adverse consequences for fetal viability, neurodevelopmental outcome and adult cardiovascular health. It is characterized by a sparse, poorly developed distal villous tree with abnormally shaped, elongated, slender villi and widening of the intervillous space. Generally, villi show widespread trophoblast abnormalities with thinning of the villous trophoblast layer, reduction in cytotrophoblast numbers, evidence of a widespread increase in syncytiotrophoblast nuclear senescence and wave-like syncytial knots. Investigation of pregnancies with false positive serum screening tests for fetal aneuploidy/structural defects can help identify pregnancies at risk of placental insufficiency, particularly when combined with ultrasound assessment of placental morphology at 19–22 weeks. Identification of pregnancies with multiple abnormal tests of placental function permits high-risk specialist referral to optimize maternal-fetal outcome.Distal villous hypoplasiaBrendan Fitzgerald, John Kingdom, Sarah Keating10.1016/j.mpdhp.2012.02.005Diagnostic Histopathology 18, 5 (2012)2012-03-29Diagnostic Histopathology2012-03-29185S1756-2317(12)X0005-7Mini-Symposium: Placental and Trophoblastic Pathology195200http://www.diagnostichistopathology.co.uk/article/PIIS1756231712000382/abstract?rss=yesAbstract: Hydatidiform moles represent a fascinating group of trophoblastic proliferative disorders with unique genetic compositions and often challenging morphologic features for diagnosis. While conventional histomorphology remains the cornerstone of the diagnosis of molar gestations, there has been an ongoing search for the past three decades for new diagnostic modalities to aid the pathologist. In this review first we will discuss the histopathologic features of molar gestations and their mimics, including non-molar hydropic abortions, chromosomal trisomy syndromes, digynic non-molar triploidy and placental mesenchymal dysplasia. Then we will focus on the conventional and novel ancillary techniques – ploidy analysis, fluorescent in situ hybridization, immunohistochemistry and molecular genotyping – and their role in the diagnostic algorithm.New diagnostic modalities in the histopathological diagnosis of hydatidiform molesNatalia Buza, Pei Hui10.1016/j.mpdhp.2012.02.004Diagnostic Histopathology 18, 5 (2012)2012-03-26Diagnostic Histopathology2012-03-26185S1756-2317(12)X0005-7Mini-Symposium: Placental and Trophoblastic Pathology201209http://www.diagnostichistopathology.co.uk/article/PIIS1756231712000357/abstract?rss=yesAbstract: Triple-negative breast cancers (TNBC) are a heterogeneous group of breast cancers defined by their lack of expression of oestrogen and progesterone receptors as well as human epidermal growth factor receptor 2 amplification, and therefore, are resistant to hormonal and Trastuzumab therapy. TNBC accounts for 15% of all breast cancers, and are more common in African-American women than in Whites. Also, BRCA-1 associated tumours are usually TNBC. Since the majority of TNBC fall into the basal-like breast cancer category by molecular studies, they are generally regarded as tumours of poor prognosis. However, some TNBC, such as adenoid cystic carcinoma and medullary carcinomas have excellent prognosis. Others, like metaplastic carcinoma have a prognosis that is comparable to infiltrating ductal carcinoma, not otherwise specified (NOS). Many immunohistochemical markers have been studied as an adjunct tool in classifying TNBC. However, microscopic evaluation remains an important tool in classifying these tumours and therefore predicting their prognosis.Triple negative breast carcinoma: the good, the bad and the uglyDina Kandil, Ashraf Khan10.1016/j.mpdhp.2012.02.001Diagnostic Histopathology 18, 5 (2012)2012-03-29Diagnostic Histopathology2012-03-29185S1756-2317(12)X0005-7Review210216http://www.diagnostichistopathology.co.uk/article/PIIS1756231712000370/abstract?rss=yesPaediatric pathologyGordan M. Vujanić10.1016/j.mpdhp.2012.02.003Diagnostic Histopathology 18, 5 (2012)2012-03-26Diagnostic Histopathology2012-03-26185S1756-2317(12)X0005-7Self-Assessment217220